March 22, 2021

Euan Angus Ashley

Harvard Book Store's virtual event series, the Harvard University Division of Science, and the Harvard Library welcome EUAN ANGUS ASHLEY—professor of Medicine and Genetics at Stanford University—for a discussion of his latest book, The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them. He will be joined in conversation by SIDDHARTHA MUKHERJEE, pioneering physician and author of the Pulitzer Prize–winning book, The Emperor of All Maladies: A Biography of Cancer.

Details

Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000.

For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.

In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures.

He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.

These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

About Author(s)

Euan Angus Ashley is a Professor of Medicine and Genetics at Stanford University. He was born in Scotland and graduated from the University of Glasgow. After completing a PhD at Oxford University, he joined the Stanford faculty, where he led the team that carried out the first medical interpretation of a human genome. Ashley has received awards from the National Institutes of Health and the American Heart Association. He was recognized by the Obama White House and received the Medal of Honor from the American Heart Association. His articles have appeared in the many journals, including Lancet, the New England Journal of Medicine, the Journal of the American Medical AssociationNature and Cell.

Siddhartha Mukherjee is a pioneering physician, oncologist, and author who has redefined our public discourse on human health, medicine and science. A profoundly influential voice in the scientific community, he is best known for his books, The Emperor of All Maladies: A Biography of Cancer, which earned him the 2011 Pulitzer Prize, and The Gene: An Intimate History which won international awards and was recognized by The Washington Post and the New York Times as one of the most influential books of 2016. He writes for the New YorkerThe New York Times Magazine and many other publications, has received numerous awards for his scientific work, has published his original research and opinions in journals such NatureCell and the New England Journal of Medicine, and lives in New York City with his wife and daughters.